JPH0549668B2 - - Google Patents

Info

Publication number
JPH0549668B2
JPH0549668B2 JP63310354A JP31035488A JPH0549668B2 JP H0549668 B2 JPH0549668 B2 JP H0549668B2 JP 63310354 A JP63310354 A JP 63310354A JP 31035488 A JP31035488 A JP 31035488A JP H0549668 B2 JPH0549668 B2 JP H0549668B2
Authority
JP
Japan
Prior art keywords
sup
formula
group
lower alkoxy
benzene ring
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP63310354A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0272170A (ja
Inventor
Tameo Iwasaki
Koki Takashima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Tanabe Pharma Corp
Original Assignee
Tanabe Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co Ltd filed Critical Tanabe Seiyaku Co Ltd
Priority to JP63310354A priority Critical patent/JPH0272170A/ja
Publication of JPH0272170A publication Critical patent/JPH0272170A/ja
Publication of JPH0549668B2 publication Critical patent/JPH0549668B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/94—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of polycyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/92—Naphthofurans; Hydrogenated naphthofurans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
    • C07C63/33—Polycyclic acids
    • C07C63/337—Polycyclic acids with carboxyl groups bound to condensed ring systems
    • C07C63/34—Polycyclic acids with carboxyl groups bound to condensed ring systems containing two condensed rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
    • C07C65/24—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/70—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with ring systems containing two or more relevant rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Furan Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
  • Lubricants (AREA)
  • Fats And Perfumes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Saccharide Compounds (AREA)
JP63310354A 1985-01-10 1988-12-08 ナフトエ酸ラクトン誘導体 Granted JPH0272170A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP63310354A JPH0272170A (ja) 1985-01-10 1988-12-08 ナフトエ酸ラクトン誘導体

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP60-3090 1985-01-10
JP309085 1985-01-10
JP63310354A JPH0272170A (ja) 1985-01-10 1988-12-08 ナフトエ酸ラクトン誘導体

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP61002624A Division JPS61267541A (ja) 1985-01-10 1986-01-08 抗脂血剤

Publications (2)

Publication Number Publication Date
JPH0272170A JPH0272170A (ja) 1990-03-12
JPH0549668B2 true JPH0549668B2 (en]) 1993-07-26

Family

ID=11547645

Family Applications (3)

Application Number Title Priority Date Filing Date
JP61002624A Pending JPS61267541A (ja) 1985-01-10 1986-01-08 抗脂血剤
JP63310353A Pending JPH0272136A (ja) 1985-01-10 1988-12-08 ナフタレン誘導体、その製法及びその合成中間体
JP63310354A Granted JPH0272170A (ja) 1985-01-10 1988-12-08 ナフトエ酸ラクトン誘導体

Family Applications Before (2)

Application Number Title Priority Date Filing Date
JP61002624A Pending JPS61267541A (ja) 1985-01-10 1986-01-08 抗脂血剤
JP63310353A Pending JPH0272136A (ja) 1985-01-10 1988-12-08 ナフタレン誘導体、その製法及びその合成中間体

Country Status (18)

Country Link
US (2) US4771072A (en])
EP (1) EP0188248B1 (en])
JP (3) JPS61267541A (en])
KR (1) KR890001884B1 (en])
CN (1) CN1006464B (en])
AT (1) ATE54441T1 (en])
AU (1) AU584153B2 (en])
BG (2) BG45383A3 (en])
DD (1) DD270529A5 (en])
DE (1) DE3672501D1 (en])
ES (2) ES8705837A1 (en])
FI (1) FI87557C (en])
HU (1) HU196737B (en])
IL (1) IL91117A0 (en])
MY (1) MY101268A (en])
NO (1) NO170760C (en])
PH (1) PH22105A (en])
PT (1) PT81814B (en])

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4644072A (en) * 1985-04-12 1987-02-17 Bristol-Myers Company Intermediates for the production of epipodophyllotoxin and related compounds and processes for the preparation and use thereof
US5011948A (en) * 1985-04-12 1991-04-30 Bristol-Myers Company Intermediates for the production of epipodophyllotoxin and related compounds and processes for the preparation and use thereof
JPS6310746A (ja) * 1986-07-01 1988-01-18 Tanabe Seiyaku Co Ltd ナフタレン誘導体
AT388372B (de) * 1987-10-08 1989-06-12 Tanabe Seiyaku Co Neue naphthalinderivate und sie enthaltende pharmazeutika
JPH01135766A (ja) * 1987-11-20 1989-05-29 Tanabe Seiyaku Co Ltd ビフェニル誘導体
PH26342A (en) * 1988-11-29 1992-04-29 Univ Texas Microbial cellulose modified during synthesis
MY105057A (en) * 1989-01-27 1994-07-30 Tanabe Seiyaku Co A process for preparing naphthalene derivatives
US5003087A (en) * 1989-02-03 1991-03-26 Tanabe Seiyaku Co., Ltd. Process for preparing a naphthalene derivative and a synthetic intermediate thereof
US5281720A (en) * 1991-02-28 1994-01-25 Merck Frosst Canada, Inc. Pyranylphenyl hydroxyalkylnaphthoic acids as inhibitors of leukotriene biosynthesis
EP0501578A1 (en) * 1991-02-28 1992-09-02 Merck Frosst Canada Inc. Pyranylphenyl hydroxyalkylnaphthoic acids as inhibitors of leukotriene biosynthesis
EP0501579A1 (en) * 1991-02-28 1992-09-02 Merck Frosst Canada Inc. Naphthalene lactones as inhibitors of leukotriene biosynthesis
US5227399A (en) * 1991-02-28 1993-07-13 Merck Frosst Canada, Inc. Pyranylphenyl naphthalene lactones as inhibitors of leukotriene biosynthesis
ES2091488T3 (es) * 1991-10-17 1996-11-01 Shionogi & Co Analogo de lignano, su produccion y medicamento hipolipidemico.
US5308852A (en) * 1992-06-29 1994-05-03 Merck Frosst Canada, Inc. Heteroarylnaphthalenes as inhibitors of leukotriene biosynthesis
US5252599A (en) * 1992-08-27 1993-10-12 Merck Frosst Canada, Inc. Heteroarylnaphthalene hydroxy acids as inhibitors of leukotriene biosynthesis
US5428060A (en) * 1992-08-27 1995-06-27 Merck Frosst Canada, Inc. Heteroarylnaphthalene lactones as inhibitors of leukotriene biosynthesis
US5350744A (en) * 1992-08-27 1994-09-27 Merck Frosst Canada, Inc. Phenylnaphthalene lactones as inhibitors of leukotriene biosynthesis
US5426109A (en) * 1992-08-27 1995-06-20 Merck Frosst Canada, Inc. Phenylnaphthalene hydroxy acids
CA2121060C (en) * 1993-04-16 2004-04-06 Sachio Mori Preparation of lignan analogues
ID18046A (id) * 1996-08-20 1998-02-19 Takeda Chemical Industries Ltd Senyawa siklik campuran, pembuatan dan penngunaannya.
CA2341540A1 (en) 1998-08-25 2000-03-02 Yale University Inhibition and treatment of hepatitis b virus and flavivirus by helioxanthin and its analogs
MXPA01012493A (es) 1999-06-01 2003-09-10 Univ Texas Southwestern Med Ct Metodo para tratar la perdida capilar con el uso de derivados de eter difenilico.
AR018699A1 (es) 1999-06-01 2001-11-28 Procter & Gamble Metodo para el tratamiento de la perdida del cabello el cual comprende administrar una composicion que comprende un compuesto el cual no afecta al corazon
US6680344B1 (en) 1999-06-01 2004-01-20 The University Of Texas Southwestern Medical Center Method of treating hair loss using diphenylmethane derivatives
SE0102168D0 (sv) * 2001-06-19 2001-06-19 Karolinska Innovations Ab New use and new compounds
AU2002328569B9 (en) * 2001-08-28 2005-10-27 Sankyo Company, Limited Medicinal compositions containing angiotensin II receptor antagonist
GB0307918D0 (en) 2003-04-05 2003-05-14 Astrazeneca Ab Therapeutic use
WO2011150286A2 (en) 2010-05-26 2011-12-01 Satiogen Pharmaceuticals,Inc. Bile acid recycling inhibitors and satiogens for treatment of diabetes, obesity, and inflammatory gastrointestinal conditions
CN107375932B (zh) 2011-10-28 2021-12-21 夏尔人类遗传性治疗公司 用于治疗小儿胆汁淤积性肝病的胆汁酸再循环抑制剂
JP6217939B2 (ja) 2011-10-28 2017-10-25 ルメナ ファーマシューティカルズ エルエルシー 高胆汁血症および胆汁うっ滞性肝疾患の処置のための胆汁酸再利用阻害剤
US20140275090A1 (en) 2013-03-15 2014-09-18 Lumena Pharmaceuticals, Inc. Bile acid recycling inhibitors for treatment of primary sclerosing cholangitis and inflammatory bowel disease
US20140271734A1 (en) 2013-03-15 2014-09-18 Lumena Pharmaceuticals, Inc. Bile acid recycling inhibitors for treatment of barrett's esophagus and gastroesophageal reflux disease
US20170119806A1 (en) * 2014-03-31 2017-05-04 Ohio State Innovation Foundation Arylnaphthalene lactone derivatives and methods of making and using thereof
US10682367B2 (en) 2016-02-26 2020-06-16 Ohio State Innovation Foundation Antitumor arylnaphthalene ligand glycosides
BR112021015809A2 (pt) 2019-02-12 2022-01-18 Mirum Pharmaceuticals Inc Resposta dependente de genótipo e dose a um asbti em pacientes com deficiência de bomba de exportação de sal biliar

Also Published As

Publication number Publication date
IL91117A0 (en) 1990-03-19
ES557052A0 (es) 1987-12-16
KR860005778A (ko) 1986-08-13
HUT42428A (en) 1987-07-28
CN86100090A (zh) 1986-08-20
AU5175185A (en) 1986-07-17
FI860089A0 (fi) 1986-01-09
EP0188248B1 (en) 1990-07-11
NO170760B (no) 1992-08-24
BG45383A3 (bg) 1989-05-15
ATE54441T1 (de) 1990-07-15
HU196737B (en) 1989-01-30
FI860089L (fi) 1986-07-11
ES550578A0 (es) 1987-05-16
FI87557B (fi) 1992-10-15
JPH0272170A (ja) 1990-03-12
PH22105A (en) 1988-06-01
FI87557C (fi) 1993-01-25
AU584153B2 (en) 1989-05-18
JPH0272136A (ja) 1990-03-12
EP0188248A3 (en) 1986-12-17
PT81814A (en) 1986-02-01
DE3672501D1 (de) 1990-08-16
MY101268A (en) 1991-08-17
US5070103A (en) 1991-12-03
BG45385A3 (bg) 1989-05-15
PT81814B (pt) 1988-07-29
NO855355L (no) 1986-07-11
NO170760C (no) 1992-12-02
ES8801239A1 (es) 1987-12-16
KR890001884B1 (ko) 1989-05-29
DD270529A5 (de) 1989-08-02
JPS61267541A (ja) 1986-11-27
EP0188248A2 (en) 1986-07-23
CN1006464B (zh) 1990-01-17
ES8705837A1 (es) 1987-05-16
US4771072A (en) 1988-09-13

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